Note that VirtualBox only allows you to use this feature with Windows, Linux, and Solaris guests.
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You can seamlessly run Windows programs on your Linux desktop or run Linux software on a Windows one. These tricks work whether you’re using Windows, Linux, or Mac. The programs are still sandboxed so they won’t have access to your host operating system’s files - they just appear to be running on the host operating system.
They’ll appear to be running as if they were running on your host operating system, but the virtual machine is still running in the background. You start up your virtual machine, launch the programs you want to use, and then enable “Seamless Mode” or “Unity Mode.” The guest operating system’s desktop and the virtual machine window will vanish, leaving the guest operating system’s windows on your desktop.